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HOME
> 種原資料庫 >
RMRC13353
RMRC No.
RMRC13353
Order
Strain/Stock Designation
B6.129-
Cdk12
tm1Fmj
Trp53
em1Fmj
/Narl
Status
EM
|
(Cryopreserved Embryos)
Availability
Level4
Pricing
(Embryos) Industry:11,105NTD Academia: 7,775NTD NSTC: 5,415NTD(Cryo Recovery) Industry:20,815NTD Academia: 13,880NTD NSTC: 13,880NTD
Last Update Date
2019/3/26
Analysis Data
Description
Genes &
alleles
Phenotype
Health &
husbandry
References
Specific Term
and Conditions
Construct map
Species
:
laboratory mouse
Strain Type
:
MSK (mutant stock),CON (congenic strain)
Mutant Type
:
TM (Target Mutation)
Other Names
:
Background Strain
:
C57BL/6
Strain Description
:
1.
Trp53
mutation in this strain is generated by CRISPR/CAS9 technique and microinjection with embryos derived from strain B6.129-
Cdk12
tm1Fm j
/Narl (RMRC13312)
2.
Deletion of Exon 3 to Exon 10 in
Trp53
occurs in this strain
3.
Homozygous mutants often develop tumors (lymphomas and sarcomas) since three to six months of age.
4.
The breeding scheme used in this strain is homozygous mutant (Cdk12
fl/fl
Trp53
-/-
) x homozygous mutant (Cdk12
fl/fl
Trp53
-/-
).
Depositor
:
Ming-Ji Fann
/
范明基
Email
:
mjfann@ym.edu.tw
Allele Symbol
:
Cdk12
tm1Fmj
Allele Name
:
cyclin-dependent kinase 12, target mutation 1, Ming-Ji Fann
Allele Description
:
Allele Symbol
:
Trp53
em1Fmj
Allele Name
:
transformation related protein 53, endonuclease-mediated mutation 1, Ming-Ji Fann
Strain of Origin
:
129
Gene Symbol
:
Cdk12
Gene Name
:
cyclin-dependent kinase 12
Chromosome
:
11
Gene Symbol
:
Trp53
Gene Name
:
transformation related protein 53
Chromosome
:
11
Genotyping Method
:
Download
Genotyping NLAC
:
Research Application
:
Cancer
Cell and Developmental Biology
Construction Technologies
:
Cre-lox system
Animal Health Reports
:
Colony Maintenance
Breeding & Husbandry
:
Colony Maintenance
Mating System
:
homo x homo
References
:
No
Specific Terms of Use
:
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果,不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時,應揭露並致謝本材料係由
Dr. Ming-Ji Fann
所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge
Dr. Ming-Ji Fann
Construct Map
:
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