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RMRC No. RMRC13283 Order
Strain/Stock Designation B6.129-Sept12tm1(D197N)Kpln
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing (Embryos) 　International：560USD
(Cryo Recovery) 　International：760USD
Last Update Date 2015/12/17
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ： 1. The entire mouse Sept12(bMQ-374d12 BAC) carried D197N mutation was transfected into 129v mouse embryonic stem cells by electroporation.
2. This strain is male infertility.
3.  SEPT12 carried D197N mutation disrupts SEPT12 filament formation, showed a disorganized sperm annulus, bent tail, reduced motility and loss of the SEPT ring structure at sperm annulus.
Depositor ：
Pao-Lin Kuo / 郭保麟
Email ： paolinkuo@gmail.com
Allele Symbol ： Sept12tm1(D197N)Kpln
Allele Name ： septin 12, target mutation 1, Pao-Lin Kuo
Allele Description ：
Strain of Origin ： 129
Gene Symbol ： Sept12
Gene Name ： septin 12
Chromosome ： 16
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Reproductive Biology
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x wild type
References ： PubMed ID: 25588830

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins
Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins
分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email: paolinkuo@gmail.com
Construct Map ：
 
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