Developing Advanced Severe Immunodeficiency Nude Mice
Assisting Patient-Derived Xenograft Transplantation and Drug Testing and a Valuable Aid to Precision Medicine

Laboratory mice serve as an essential platform for tumor drug testing, but traditional laboratory mouse models are less than ideal for transplantation of patient-derived xenograft. To optimize the test platform, NLAC has successfully developed advanced severe immunodeficiency (ASID) mice in 2017. The ASID mice have had most of their immune cells removed, enabling human tumors to grow more easily. NLAC further developed hairless ASID mice in 2018, allowing observation and more accurate measurement of tumors. This nude ASID mice are expected to be available to all researchers in 2019.